Semler Scientific (SMLR), a US-based medical technology company, has revealed plans to acquire more Bitcoin (BTC) despite facing a 5.0% unrealized loss on its previous BTC investments. 

The firm has filed a Form S-3 registration with the US Securities and Exchange Commission (SEC) to raise up to $500 million through a securities offering. The proceeds would be allocated for general corporate purposes, including expanding its Bitcoin portfolio.

Semler Scientific Files S-3 to Fund Bitcoin Investments

According to the official filing, the firm plans to issue common stock, preferred stock, debt securities, and warrants as part of the securities offering. The SEC filing does not specify the exact amount allocated for Bitcoin purchases. Nonetheless, Semler’s recent activity suggests a strong focus on cryptocurrency.

“We have not determined the amount of net proceeds to be used specifically for such purposes. As a result, management will retain broad discretion over the allocation of the net proceeds of any offering,” the filing read.

This move follows Semler’s previous acquisition of 871 BTC for $88.5 million at an average price of $101,616 per Bitcoin. The purchases were made between January 11 and February 3. 

The acquisition increased Semler’s total Bitcoin holdings to 3,192 BTC. The holdings worth $266.1 million represent 80.6% of the company’s total market capitalization of 330.1 million. This indicates that a significant portion of its value is tied to its Bitcoin investments.

“From January 1, 2025, to February 3, 2025, Semler Scientific’s BTC Yield was 21.9%. From July 1, 2024 (the first full quarter after Semler Scientific adopted its bitcoin treasury strategy) to February 3, 2025, Semler Scientific’s BTC Yield was 152.2%,” the firm revealed.

However, the tides have shifted since then. According to Bitcoin Treasuries, Semler’s average BTC acquisition cost is $87,850 per coin. As of the latest data from BeInCrypto, Bitcoin’s market price stood at $83,397, placing Semler at a 5.0% loss on its investment. 

Previously, BeInCrypto noted that the losses surged to 14.7% as BTC fell below the $80,000 mark. Despite this, Semler’s leadership appears committed to its Bitcoin strategy, viewing the cryptocurrency as a long-term store of value.

Semler’s strategic push into Bitcoin mirrors those of other firms, such as Strategy (formerly MicroStrategy) and Metaplanet. Earlier this week, the firms acquired BTC worth $285 million and $26.3 million, respectively. 

However, Semler’s decision to double down on Bitcoin comes amid financial and legal challenges. On April 15, the company announced a preliminary $29.75 million settlement with the US Department of Justice (DOJ) to resolve allegations of violating federal anti-fraud laws related to marketing its QuantaFlo product.

The settlement is pending final approval. Yet, it adds pressure to Semler’s balance sheet as it navigates its ambitious fundraising and Bitcoin investment plans.

The total value of real-world assets (RWAs) on the Arbitrum network has surged over 1,000-fold since the start of 2024.

From a modest $100,000 to $200,000 in early January last year, Arbitrum now hosts more than $200 million in tokenized RWAs. This reflects one of the most explosive growth trajectories in decentralized finance (DeFi) this year.

RWA Total Value on Arbitrum Increases 1,000X

This exponential expansion is largely attributed to Arbitrum DAO’s Stable Treasury Endowment Program (STEP), which is currently in its 2.0 phase. The program allocated 85 million ARB tokens to support stable, liquid, yield-generating RWAs.

“The DAO just approved 35M ARB for RWAs via STEP 2.0. This brings the total RWA investments from the DAO treasury to 85M ARB, one of the largest DAO-led RWA allocations in Web3,” Arbitrum said in February.

The strategy aims to reduce the DAO’s exposure to volatile native crypto assets and help build a more resilient treasury, and it appears to be yielding results.

US Treasuries dominate Arbitrum’s RWA ecosystem, making up 97% of the sector. Franklin Templeton’s BENJI leads the pack, which holds a 36% market share, followed by SPIKO’s European treasuries, accounting for 18%.

This diversification beyond US-centric instruments is a healthy sign for global institutional engagement with Arbitrum.

“The eco welcomes global diversification beyond US instruments,” The Learning Pill remarked.

New entrants like Dinari have also added to the ecosystem’s momentum, offering tokenized versions of traditional securities. These include stocks, ETFs (exchange-traded funds), and REITs via its dShares platform.

More than 18 tokenized RWA products live on Arbitrum, covering various asset classes from bonds to real estate. Arbitrum itself highlighted this institutional influx on X (Twitter)

“RWA and Stablecoin adoption on Arbitrum has been monumental! Some of the largest institutions are bringing their tokenized assets to the land of liquidity with $4.7 billion in Stablecoins and over $214 million in RWAs already onchain,” the network stated.

Teams like Securitize, DigiFT, and SPIKO are tokenizing everything from sovereign debt to real estate portfolios, signaling the early formation of a new financial substrate.

Yet, despite the strong ecosystem development, ARB, the network’s native token, is down 88% from its all-time high.

Further downside pressure looms, with a 92.63 million ARB token unlock imminent. With only 46% of the total supply currently in circulation, concerns about dilution and lack of direct token accrual from RWA growth remain key market overhangs.

Tokenized RWA Cross $11 Billion, Ethereum Dominates Onchain Finance Frontier

Beyond Arbitrum, the broader real-world asset sector has quietly become one of the most significant trends in crypto, even if it does not dominate headlines.

According to DeFiLlama, on-chain RWAs have surpassed $11.169 billion in total value locked, up 2.5X over the past year.

Tokenized US Treasuries and tokenized gold are the engines behind this boom. BlackRock’s BUIDL fund now holds over $2.38 billion in tokenized Treasuries alone. Meanwhile, blockchain-based gold assets, driven by both market demand and rising metal prices, have crossed $1.2 billion, according to a recent BeInCrypto report.

Ethereum remains in the frontline, hosting approximately 80% of all on-chain RWAs. As TradFi giants seek programmable exposure to dollar yields and real assets, Ethereum offers the infrastructure and liquidity needed to bridge capital markets with blockchain rails.

“The top RWA protocols aren’t chasing crypto narratives. They are offering something TradFi understands: yield, dollar exposure, and gold. This is not the future of DeFi. It’s the future of finance,” DeFi analyst Patrick Scott observed.

Builders point out that adoption is already deeply embedded in on-chain-native applications like Pendle, Morpho, Frax, and various automated market makers (AMMs) and staking layers. The “real yield” thesis has arrived, coded into the new financial system’s base layer.

“The TradFi narrative is nice, but the adoption so far is on-chain-native,” DeFi builder Artem Tolkachev noted.

While flashy DeFi experiments often mimic casinos, RWAs show that slow, stable, and scalable wins the race.

The next frontier lies in improving access, liquidity, and incentives, particularly on non-Ethereum chains like Arbitrum, where the technical groundwork is strong, but market confidence remains in flux.

Tokenized RWAs may not be the loudest narrative in crypto, but they are becoming its most consequential.

“Onchain RWAs are quietly becoming the backbone of future finance, not hype, just real value TradFi gets: yield, dollars, and gold,” Validatus.com quipped.